Diaphragm valves

High purity Weirless Radial diaphragm valves for aseptic processing

Diaphragm valves - the highest quality bioprocessing valves

For over 30 years ASEPCO® have been developing the highest quality diaphragm valves for aseptic processing.

We are trusted by bioprocessing engineers worldwide for developing stainless steel valve products that deliver cost savings, accelerate process and maintenance times—while reducing the risk of contamination.

Today we manufacture the aseptic processing industry’s diaphragm valve of choice.

  • No tools or special training required
  • Integrated, non-adjustable travel stops
  • No dead legs or dead spaces
  • Flush mount design and simple clamp assembly

Bioprocessing diaphragm valves that minimise contamination risk and save 80% maintenance time




The diaphragm seal moves independently of the shoulder seal (the seal between the inside and outside of the valve). Using a manual or pneumatic actuator, you can easily open and close the seal. The cylindrical shape of the diaphragm, when squeezed into the sealing position, holds the seal—tested to an internal water pressure of up to 20 bar (varies depending on diaphragm material and actuator type) without leakage.

When the valve is closed, the unique CIP/SIP “behind-the-seat flow path” can be created if you add a CIP or SIP port. This flow path makes it easy to steam or clean the valve while the valve is closed. This allows for validated aseptic and sterile system connections and transfers to be performed. Combined these features save time and money by reducing maintenance time, improving performance with a less restrictive flow path.

Challenging conventional design

The design of the basic weir-style diaphragm valve seal presents a number of issues for process engineers working in the biotechnology and pharmaceutical industry.

In typical configurations, a weir in the valve body rises in a fluid path and when the valve is closed, the diaphragm meets the weir to shut off the flow.

While a simple technology intended to reduce turbulence and shear, weir-style valves present a number of issues, for example in upstream processing applications they can be difficult to install, prone to leaks, and increase the potential of product contamination.

In traditional weir valves, a seal is made by placing a diaphragm between the mating faces of the valve body and actuator. This assembly is then held together with a set of nuts and bolts. The valve bodies are made from stainless steel due to its outstanding chemical compatibility outstanding corrosion resistance when exposed to repeated clean-in-place (CIP) and steam-in-place (SIP) cycles.


  • Fully traceable materials Valves are made from fully traceable materials, regardless of the type of alloy you choose, ensuring they meet your local standards and codes.
  • Long-lasting surface finish They are fully machined, electropolished and passivated as standard, giving you a consistent, long-lasting surface finish.
  • Saves you time and money Our valves are designed to save you time and money. Changing a diaphragm only takes seconds, making your valves simple to inspect, clean and use
  • Quality you can rely on We inspect every valve - not just a representative sample. Each valve has passed stringent quality tests at every stage of production.


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