Tubing - peristaltic

Bioprene - Thermoplastic tubing

Overview

Bioprene: thermoplastic tubing ideal for critical processes requiring accurate, reliable and repeatable performance

Bioprene peristaltic pump tubing is USP Class VI and FDA compliant and suitable for biopharmaceutical and food applications.

Bioprene's exceptionally long peristaltic life ensures process security, thereby reducing risk in critical cGMP applications. Bioprene is a thermoplastic elastomer tube which is produced from synthetic components. No natural rubber (such as latex) is used in the production of Bioprene tubing. The raw material has been fully tested to USP Class VI and conforms to NSF51.

Bioprene is widely applicable in biopharmaceutical manufacturing operations such as metering, transfer and filtration, along with a variety of applications within the food and beverage industry.

Operating pressures of 0 to 2 bar can be achieved with Bioprene continuous tubing. A range of LoadSure tube elements increase the pressure capability up to a maximum of 7 bar.

Chemical Compatibility Guide

Features and benefits

  • Certification: USP Class VI and FDA regulation 21CFR 177:2600 for contact with aqueous food
  • Sterilisable by gamma irradiation and autoclaving
  • Available as standard in 15 different bore sizes (13 for elements), five wall thicknesses (3 for elements) and three coil lengths, including bulk reels and LoadSure elements. Other sizes available on request.
  • Operating temperature: 5 ºC to 80 ºC
  • Colour/transparency: Beige/opaque
  • Spallation: Low

Technical summary

CertificationFDA 21CFR177.2600, NSF51 listed, USP Class VI 
Shelf life5 years
Gamma stability25-40 kGy 
Autoclave stability121 °C 30 minutes 

Technical Summary table lists features available within the range. See ‘Specifications’ tab for model specific information.

Specifications

Technical specifications

BiopreneBioprene elements
Autoclave stability121 °C 30 minutes 121 °C 30 minutes 
CertificationFDA 21CFR177.2600, NSF51 listed, USP Class VI FDA 21CFR177.2600, NSF51 listed, USP Class VI 
ColourBeige Beige 
Compatible pumpheads313D, 313D2, 314D, 314D2, 520R, 520R2, 620R, 720R 505L, 520REL, 520REM, 620L, 620RE, 620RE4, 720RE 
Gamma stability25-40 kGy 25-40 kGy 
Gas permeability ratingLow Low 
SpallationLow Low 
TransparencyOpaque Opaque 
UV resistance Excellent Excellent 
Water absorptionLow Low 
Shelf life5 years5 years
Bore size0.02 - 1 in0.0625 - 1 in
Bore size0.5 - 25.4 mm1.6 - 25.4 mm
Compression set5 to 42.5 %5 to 42.5 %
Elongation at break340 to 600 %340 to 600 %
Hardness, shore A (5sec)62 to 68 62 to 68 
Length10 - 500 Ft
Length3 - 152 m
Specific gravity0.95 to 0.98 0.95 to 0.98 
Tensile stress at 100% elongation1.9 to 3 Mpa1.9 to 3 Mpa
Ultimate tensile strength55 to 690 bar55 to 690 bar
Ultimate tensile strength798 to 9999 psi798 to 9999 psi
Wall thickness0.0625 - 0.1875 in0.09375 - 0.2 in
Wall thickness1.6 - 4.8 mm2.4 - 4.8 mm
Weight0.09 - 8 kg0.2 - 0.67 kg
Weight0.2 - 17.64 lbs0.44 - 1.48 lbs
Operating temperature range 5 to 80°C5 to 80°C
Operating temperature range 41 to 176 °F41 to 176 °F
ASTM methods Hardness: ASTM D 2240; Specific gravity: ASTM D 792; Tear B, Ultimate tensile strength, Elongation at break, Tensile stress at 100 % elongation; ASTM D 412

Materials of construction

TubingThermoplastic elastomer
Connector materialPVDF

Literature

Brochures

  1. Bioprocessing industry (US).pdf
    PDF - 2.9mb
  2. Tubing overview (EN).pdf
    PDF - 841.6kb

Datasheet

  1. Bioprene datasheet (EN).pdf
    PDF - 314.8kb

Production and Packaging

Production

Watson-Marlow Bioprene tubing is a high purity product which is produced in a state-of-the-art ISO 14644-1 Class 7 cleanroom facility according to cGMP principles operating an ISO9001:2008 quality system. The final tubing product is compliant with USP Class VI, including USP and USP, and FDA 177:2600 for contact with aqueous food. A DMF (Drug Master File) has also been established with the US FDA.

Bioprene is a thermoplastic elastomer tube which is produced from synthetic components. No natural rubber (such as latex) is used in the production of Bioprene tubing. The raw material has been fully tested to USP Class VI and conforms to NSF51.

Watson-Marlow Bioprene tubing is manufactured from virgin pellet only: no regrind is used in the production of Bioprene. Full traceability is assured through the lot number of the tubing, which enables the raw material, primary manufacturing equipment, quality control records and production records to be identified.

Packaging

Bioprene tubing is double-packed, in heat-sealed polythene bags in the cleanroom. The bags are labelled with the Bioprene part number, lot number, use-by date and tube description. The standard coil length is 50 feet (15 m), other coil lengths or cut lengths are available on request.

Tubing reels, which include up to 500 feet (152 m) of tubing, are also available for 1.6, 2.4 and 3.2 mm wall tubing. The bagged Bioprene coils and reels are packed in a card box outside the cleanroom. The card boxes are labelled with the Bioprene part number, lot number, use-by date and tube description. A lot-specific certificate of conformance is included with each pack of tubing.

Full lot traceability is maintained for every batch of tubing produced through detailed raw material and production records, hard copy and electronic production data and retained samples. Also download a copy of certificate of conformance for Watson-Marlow sanitary tubing and sanitary tubing elements. The raw material is manufactured under strict controls of ingredients, operating procedures and packaging.

Traceability

All tubing packaging is labelled with the product description, part and lot numbers, use-by date and a barcode of this information. Included in the box is the certificate of conformance. As part of the Watson-Marlow ISO9001:2008 system, lot records and process data are stored for all tubing produced in the plant.

Full lot traceability to raw material supply is therefore assured. All records are kept for the shelf life of the tubing. The plastic packaging used in direct contact with the tubing is also lot traceable and, as with the tubing, all lot records are kept for the shelf life of the tubing.

A sample of every production batch of Bioprene tubing is retained for reference.

Bulk tubing

If you buy large volumes of Bioprene tubing, Watson-Marlow can supply tubing in the way that best suits your production needs.

  • Custom tube sizes to suit your specific application
  • Custom coil lengths to suit your production requirements
  • Tubing on 500 feet (152 m)'* reels, ideal for higher volume applications
  • Custom cut lengths to fit your process; this eliminates on-site cutting and ensures the tubing is ready for use
  • Packaging to suit your needs - single bag, double bag, gamma radiation traceable, individually packed cut lengths, bulk packed
  • Custom labelling ensures your part numbers are included on all packaging
  • We can provide custom sizes and packaging, and guaranteed response times, delivered on time, every time
  • Competitive pricing

*Reel length varies with tube size

Order Information

Product codes

Bioprene product codes

Tube ordering codes
Bore Wall Coil Size
mm inch mm inch 15m/50ft 5m/16ft 152m/500ft
0.5 1/50 1.6 1/16 933.0005.016 933.0005.J16 933.0005.R16
0.8 1/32 1.6 1/16 933.0008.016 933.0008.J16 933.0008.R16
1.6 1/16 1.6 1/16 933.0016.016 933.0016.J16 933.0016.R16
2.4 3/32 1.6 1/16 933.0024.016 933.0024.J16 933.0024.R16
3.2 1/8 1.6 1/16 933.0032.016 933.0032.J16 933.0032.R16
4.8 3/16 1.6 1/16 933.0048.016 933.0048.J16 933.0048.R16
6.4 1/4 1.6 1/16 933.0064.016 933.0064.J16 933.0064.R16
8 5/16 1.6 1/16 933.0080.016 933.0080.J16 933.0080.R16
1.6 1/16 2.4 3/32 933.0016.024 933.0016.J24 933.0016.R24
3.2 1/8 2.4 3/32 933.0032.024 933.0032.J24 933.0032.R24
122m/400ft
4.8 3/16 2.4 3/32 933.0048.024 933.0048.J24 933.0048.R24
91m/300ft
6.4 1/4 2.4 3/32 933.0064.024 933.0064.J24 933.0064.R24
61m/200ft
8 5/16 2.4 3/32 933.0080.024 933.0080.J24 933.0080.R24
46m/150ft
9.6 3/8 2.4 3/32 933.0096.024 933.0096.J24 933.0096.R24
4.8 3/16 3.2 1/8 933.0048.032 - -
3m/10ft 61m/200ft
6.4 1/4 3.2 1/8 933.0064.032 933.0048.I32 933.0064.R32
46m/150ft
9.6 3/8 3.2 1/8 933.0096.032 933.0096.I32 933.0096.R32
12.7 1/2 3.2 1/8 933.0127.032 933.0127.I32 -
15.9 5/8 3.2 1/8 933.0159.032 933.0159.I32 -
8 - 4 - 933.0080.040 933.0080.I40 -
12 - 4 - 933.0120.040 933.0120.I40 -
16 - 4 - 933.0160.040 933.0160.I40 -
9.6 3/8 4.8 3/16 933.0096.048 933.0096.I48 -
12.7 1/2 4.8 3/16 933.0127.048 933.0127.I48 -
15.9 5/8 4.8 3/16 933.0159.048 933.0159.I48 -
19 3/4 4.8 3/16 933.0190.048 933.0190.I48 -
25.4 1 4.8 3/16 933.0254.048 933.0254.I48 -

Bioprene elements product codes

Bioprene Double Segment Kynar Y-Element ordering codes
Bore Wall Thickness Product codes
mm inch mm inch
1.6 1/16 2.4 3/32 933.E016.K24
3.2 1/8 2.4 3/32 933.E032.K24
4.8 3/16 2.4 3/32 933.E048.K24
6.4 1/4 2.4 3/32 933.E064.K24
8.0 5/16 2.4 3/32 933.E080.K24
8.0 5/16 4.0 5/32 933.E080.K40
9.6 3/8 2.4 3/32 933.E096.K24
12.0 15/32 4.0 5/32 933.E120.K40
16.0 5/8 4.0 5/32 933.E160.K40 -
Bioprene Loadsure Elements ordering codes
Product Name Product codes
Bioprene 520 LoadSure Tl 6.4mm Bore Tri-Clamp Element 933.0064.PFT
Bioprene 520 LoadSure Tl 3.2mm BoreTri-Clamp Element 933.0032.PFT
Bioprene 520 LoadSure Tl 9.6mm Bore Tri-Clamp Element 933.0096.PFT
Bioprene 620 LoadSure Tl 12mm Bore Tri-Clamp Element 933.0120.PFT
Bioprene 620 LoadSure Tl 17mm Bore Tri-Clamp Element 933.0170.PFT
Bioprene 720 LoadSure 12.7mm Bore Tri-Clamp Element 933.0127.PFT
Bioprene 720 LoadSure 15.9mm Bore Tri-Clamp Element 933.0159.PFT
Bioprene 720 LoadSure 19mm Bore Tri-Clamp Element 933.0190.PFT
Bioprene 720 LoadSure 25.4mm Bore Tri-Clamp Element 933.0254.PFT -

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Bioprene tubing - exceptionally long life peristaltic tubing

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